The immune system of many people fails to differentiate between healthy cells from invading microorganisms. This is leading to greater suffering throughout the world. They are now being attacked by defenses against disease that were previously used to protect them.
Research efforts across the globe are accelerating to combat this trend. A prime illustration is the London Francis Crick Institute initiative where James Lee and Carola Vinesa two experts from around the world in the area, have formed separate research groups to help to determine the exact causes of autoimmune disorders.
Lee said that autoimmune cases are on the rise since the past 40 years, in the west. New cases are being reported in countries where these diseases have never been seen before.
For example, the Middle East and East Asia are the regions with the highest number of cases of inflammatory intestinal disease. Prior to that, they had never ever heard of the disease.
Type 1 diabetes can be associated with rheumatoid or multiple sclerosis. In all cases your immune system gets confused and shifts to healthy tissue over infective agents.
The UK has at least 4,000,000 patients suffering from these diseases. There are also numerous other. According to global estimates the amount of patients suffering from autoimmune disorders is increasing by anywhere from 3% to 9percent each year. Many scientists believe environmental factors are the primary cause of this growth.
Human genetics hasn't changed in the last several years, according to Lee, who was previously based at Cambridge University. Therefore, something is changing outside of our body that can increase our risk of developing autoimmune disease.
Vinuesa was the person who was the one who believed in this concept. Vinuesa was previously at the Australian National University. She pointed to the changes in food habits that were occurring as more and more countries adopted western-style diets , and people bought more fast food.
Vinuesa said that fast food meals contain a few essential ingredients, such as fiber. Research suggests that this alteration can affect a person's microbiome that is the collection of microorganisms in our digestive. These microorganisms play a crucial role in controlling many bodily functions.
The changes in our microbiomes trigger autoimmune disorders, of which there are more than 100 kinds.
The scientists both stressed that everyone is at risk of developing these illnesses, which include celiac, Lupus, and other ailments, such as celiac, which cause inflammation and swelling and can cause serious harm to different organs.
"If you don't possess a specific genetic susceptibility to autoimmune disease, you won't necessarily get an autoimmune disorder regardless of the amount of Big Macs you eat," said Vinuesa. "There's nothing we can prevent the world-wide growth of fast food franchises. Instead, we're working to figure out how autoimmune conditions can be caused and what genetic causes can make some people more susceptible than others. This is how we want to solve the problem."
Scientists are now able to spot tiny variations in DNA between large numbers of individuals. This is possible because of the advancement of technology. It is now possible to Check out discern common genetic patterns that are common to those who suffer from an autoimmune disease.
Lee said that until very recently we didn't have the tools to sequence DNA. But now, we have this amazing power and it has changed everything. We had only half a dozen different variants of DNA that could trigger inflammation in the bowel when I started my research. Now we know of over 250.
Lee and Vinuesa have a particular focus of their efforts on this type of research. They want to learn more about genetic pathways that are involved and find the causes of the different diseases they're studying. Vinuesa said that there are a variety of variations of autoimmune diseases, including Lupus. This can have a negative influence on your ability determine the best treatment.
Although there are many potentially beneficial new treatments in the pipeline but we aren't sure the patients they should be offered to. This is because we do not know the exact type of their condition. This is an important aspect in research into autoimmune diseases. It is essential to learn how to categorize and group patients in order to give them the appropriate treatment.
Lee explained that the increasing incidence of autoimmune disease around the globe mean that new treatments and medications are needed now more than ever. There are currently no treatments for autoimmune disease that are most often seen in young peoplewho are trying to get their first job, graduate from the school year, and also raise their families.
This means that more people are likely to undergo surgery or frequent injections during their lives. This can be very difficult for patients as well as a huge burden on healthcare services. We need new and effective treatment methods.
Rheumatoid arthritis is an immune-mediated disease. This is an unanswered mystery.
Your immune system naturally produces antibodies that fight off viruses and bacteria.
If you have Rheumatoid Arthritis Your immune system mistakenly releases antibodies into your joint' lining, where they target the tissues around them.
This causes the thin, cells-like layer of your joints (synovium) to become irritated and painful this releases chemicals that cause harm around the joint.
bones
Cartilage is the stretchy connective tissue connecting bones
Tendons are connective tissue that connects bone and muscle.
Ligaments - The tissues that connects bone to cartilage
Rheumatoid arthritis can be treated but not controlled. The chemicals can cause the joint to become unbalanced and distorted. It could eventually cause the destruction of the joint.
Though there are many theories about how the immune system targets joints, none of them have been proven.
Possible risk factors
You could be more at risk of developing rheumatoid arthritis if you do the following:
You can inherit it from your genes. While there are indications that rheumatoid arthritis could be passed Click here through families, the chances of getting it are slim because genes play a tiny role in the disease.
Hormones-Rheumatoid Ailment is more common among women than in men. It could be due to the estrogen effects, but this isn't confirmed.
Smoking is a risk factor - Research suggests that those who smoke are more likely develop rheumatoid arthritis.